منابع مشابه
Hypoalbuminaemia and propofol pharmacokinetics.
Editor—Cavaliere and colleagues report that hypoalbuminaemia does not affect the accuracy of Diprifusor during sedation with propofol. They hypothesized that hypoalbuminaemia may affect the accuracy of target-controlled infusion (TCI) by introducing major deviations in propofol pharmacokinetics. Their results, however, failed to show significant differences in the accuracy of the Diprifusor bet...
متن کاملPopulation pharmacokinetics of propofol: a multicenter study.
BACKGROUND Target-controlled infusion is an increasingly common type of administration for propofol. This method requires accurate knowledge of pharmacokinetics, including the effects of age and weight. The authors performed a multicenter population analysis to quantitate the effects of covariates. METHODS The authors analyzed 4,112 samples of 270 individuals (150 men, 120 women, aged 2-88 yr...
متن کاملPropofol pharmacokinetics in children with biliary atresia.
We studied the pharmacokinetics of an i.v. bolus dose of propofol 2.5-3.0 mg kg-1 in eight children (age 4-24 months) with biliary atresia and in six control (ASA I) children (age 11-43 months). Blood samples were obtained for 4 h after administration of propofol. Blood concentrations of propofol were measured by high pressure liquid chromatography. Systemic clearance of propofol (CI) and volum...
متن کاملPharmacokinetics of an infusion of propofol during cardiac surgery.
We have measured whole blood concentrations and pharmacokinetics of propofol administered as a constant rate infusion during cardiac surgery. Ten patients undergoing elective cardiac surgery involving cardiopulmonary bypass (seven myocardial revascularization and three aortic valve surgery) received a continuous infusion of propofol 4 mg kg-1 h-1 to supplement alfentanil analgesia. Whole blood ...
متن کاملPharmacokinetics of propofol in rainbow trout following bath exposure.
Propofol, 2,6-diisopropylphenol, seems to be a good candidate as a fish anaesthetic, however, no study regarding propofol influence on fish has yet been reported. The aim of this study was to examine propofol pharmacokinetics in rainbow trout (Oncorhynchus mykiss) following bath exposure. Fish (n = 100) were exposed to an aqueous propofol bath at 12°C and 17°C; propofol concentration in the bat...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1991
ISSN: 0007-0912
DOI: 10.1093/bja/66.4.527